at the Advanced Science Research Center
Elbaum-Garfinkle Lab


Fisher, R.S, Jimenez, R.M, Soto, E., Kalev, D.,  Elbaum-Garfinkle, S. (2021) An apparent core/shell architecture of polyQ aggregates in the aging Caenorhabditis elegans neuron, Protein Science, 30(7):1482-1486


Fisher, R.S, Elbaum-Garfinkle, S. (2020) Tunable multiphase dynamics of arginine and lysine liquid condensates, Nature Communications, 11:4628


Elbaum-Garfinkle, S. (2019) Matter over mind: Liquid phase separation and neurodegeneration, J. Biol. Chem, In Press

                        -F1000 Recommended

Ceballos, A.*, McDonald, C.J.*, Elbaum-Garfinkle, S. (2018) Methods and Strategies to Quantify Liquid Phase Separation of Disordered Proteins. Methods in Enzymology, 611:31-50. * Contributed equally


Melo, A.M., Elbaum-Garfinkle, S., Rhoades, E. (2017) Insights Into Tau Function and Dysfunction Through Single Molecule Fluorescence, Methods in Cell Biology, 141:27-44.


Wei, M.T.*, Elbaum-Garfinkle, S.*, Holehouse, A.S.*, Chen, C.C., Feric, M., Arnold, C.B., Priestly, R.D., Pappu, R.V., Brangwynne, C.P. (2017) Phase Behavior of Disordered Proteins Underlying Low Density and High Permeability of Liquid Organelles, Nature Chemistry, 9:1118-1125. *Contributed equally


Melo, A.M., Coraor, J.*, Cobb, G.*, Elbaum-Garfinkle, S.*, Nath, A., Rhoades, E. (2016) A Functional Role for Intrinsic Disorder in the Tau-Tubulin Complex, Proceedings of the National Academy of Sciences USA , 113(50):14336-14341. * Contributed equally


Taylor, N., Elbaum-Garfinkle, S., Vaidya, N., Zhang, H., Stone, H.A., Brangwynne, C.P. (2016) Biophysical Characterization of Organelle-Based RNA/Protein Liquid Phases Using Microfluidics, Soft Matter, 12:9142-9150.


Elbaum-Garfinkle, S and Brangwynne, C.P. (2015) Liquids, Fibers, and Gels: The Many Phases of Neurodegeneration, Developmental Cell 35(5):531-532.


Zhang, H., Elbaum-Garfinkle, S. Langdon, E., Taylor, N., Occhipinti, P., Bridges, A., Brangwynne, C.P., Gladfelter, A.S. (2015) RNA Controls PolyQ Protein Phase Transitions, Molecular Cell 60(2):220-230.

-Featured in Guo, L., Shorter, J. (2015) It’s raining liquids: RNA tunes viscoelasticity and dynamics of membraneless organelles, Molecular Cell 60(2):189-192


Elbaum-Garfinkle, S Kim, Y., Szczepaniak, K., Chen, C.C., Eckmann, C.R., Myong, S., Brangwynne, C.P. (2015) The Disordered P Granule Protein LAF-1 Drives Phase Separation into Liquid Droplets with Tunable Viscosity and Dynamics., Proceedings of the National Academy of Sciences USA, 112(23):7189-7194.           

            -F1000 Recommended: Vladmir Uversky, 5 June, 2015 “Exceptional”

            -Featured in Dolgin, E. (2018) Cell Biology’s New Phase, Nature 555(300-302)


Elbaum-Garfinkle, S., Cobb, G., Compton, J.M., Li, Xiaohan, Rhoades, E. (2014) Tau Mutants Bind Tubulin Heterodimers With Enhanced Affinity. Proceedings of the National Academy of Sciences USA, 111(17):6311-6.


Nath, A., Sammalkorpi, M., DeWitt, D.C., Trexler, A.J., Elbaum-Garfinkle, S., O’hern, C.S., Rhoades, E. (2012). The Conformational Ensembles of alpha-Synuclein and Tau: Combining Single-Molecule FRET and Simulations. Biophysical Journal 103(9):1940- 49.


Elbaum-Garfinkle, S., Rhoades, E. 2012. Identification of an Aggregation-Prone Structure of Tau. Journal of the American Chemical Society, 134(40):16607-13.           

            –JACS Spotlight

            -Featured in Wolf, L (2012) A detailed look at tau. Chemical and Engineering News, 90, 41.

Elbaum-Garfinkle, S. (2011) Close to home: A history of Yale and Lyme Disease.  Yale Journal of Biology and Medicine., 84(2): 103-108.

Elbaum-Garfinkle, S., Ramlal, T., Rhoades, E. 2010. The Role of the Lipid Bilayer in Tau Aggregation. Biophysical Journal, 98(11):2722-30.